Protein name:
Parathyroid hormone-related protein (PTH-rP;PTHrP) ;
Alternative:
Parathyroid hormone-like protein (PLP) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
PTHrP interacts with PTH1R (via N-terminal extracellular domain).
Function:
Osteostatin is a potent inhibitor of osteoclastic bone resorption.
Subcellular Location:
Cytoplasm
Nucleus
Secreted
Protein Attributes:
50:
MQRRLVQQWS | VAVFLLSYAV | PSCGRSVEGL | SRRLKRAVSE | HQLLHDKGKS |
100:
IQDLRRRFFL | HHLIAEIHTA | EIRATSEVSP | NSKPSPNTKN | HPVRFGSDDE |
150:
GRYLTQETNK | VETYKEQPLK | TPGKKKKGKP | GKRKEQEKKK | RRTRSAWLDS |
177:
GVTGSGLEGD | HLSDTSTTSL | ELDSRRH
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Bovine
Chicken
Mouse
Rabbit
Dog
ELISA Kit for Human PTH-rP
ELISA Kit for Human PTH-rP
ELISA Kit for Human PTH-rP
ELISA Kit for Human PTH-rP
ELISA Kit for Human PTH-rP
ELISA Kit for Human PTH-rP
ELISA Kit for Human PTH-rP
CLIA Kit for Human PTH-rP
CLIA Kit for Human PTH-rP
CLIA Kit for Human PTH-rP
CLIA Kit for Human PTH-rP
CLIA Kit for Human PTH-rP
CLIA Kit for Human PTH-rP
CLIA Kit for Human PTH-rP
Polyclonal Antibody for Human PTH-rP
Polyclonal Antibody for Human PTH-rP
Polyclonal Antibody for Human PTH-rP
Polyclonal Antibody for Human PTH-rP
Polyclonal Antibody for Human PTH-rP
Polyclonal Antibody for Human PTH-rP
Polyclonal Antibody for Human PTH-rP
Monoclonal Antibody for Human PTH-rP
Monoclonal Antibody for Human PTH-rP
Monoclonal Antibody for Human PTH-rP
Monoclonal Antibody for Human PTH-rP
Monoclonal Antibody for Human PTH-rP
Monoclonal Antibody for Human PTH-rP
Monoclonal Antibody for Human PTH-rP
R&D Technical Data
12% SDS-PAGE analysis
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Precision
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Recovery
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Linearity
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References
1.
"A parathyroid hormone-related protein implicated in malignant hypercalcemia: cloning and expression."
Suva L.J.
,
Winslow G.A.
,
Wettenhall R.E.H.
,
Hammonds R.G.
,
Moseley J.M.
,
Diefenbach-Jagger H.
,
Rodda C.P.
,
Kemp B.E.
,
Rodriguez H.
,
Chen E.Y.
,
Hudson P.J.
,
Martin T.J.
,
Wood W.I.
Science237:893-896(1987)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA];PARTIAL PROTEIN SEQUENCE
2.
"Identification of a cDNA encoding a parathyroid hormone-like peptide from a human tumor associated with humoral hypercalcemia of malignancy."
Mangin M.
,
Webb A.C.
,
Dreyer B.E.
,
Posillico J.T.
,
Ikeda K.
,
Weir E.C.
,
Stewart A.F.
,
Bander N.H.
,
Milstone L.
,
Barton D.E.
,
Francke U.
,
Broadus A.E.
Proc. Natl. Acad. Sci. U.S.A.85:597-601(1988)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
6.
Mural R.J.
,
Istrail S.
,
Sutton G.G.
,
Florea L.
,
Halpern A.L.
,
Mobarry C.M.
,
Lippert R.
,
Walenz B.
,
Shatkay H.
,
Dew I.
,
Miller J.R.
,
Flanigan M.J.
,
Edwards N.J.
,
Bolanos R.
,
Fasulo D.
,
Halldorsson B.V.
,
Hannenhalli S.
,
Turner R.
,
Yooseph S.
,
Lu F.
,
Nusskern D.R.
,
Shue B.C.
,
Zheng X.H.
,
Zhong F.
,
Delcher A.L.
,
Huson D.H.
,
Kravitz S.A.
,
Mouchard L.
,
Reinert K.
,
Remington K.A.
,
Clark A.G.
,
Waterman M.S.
,
Eichler E.E.
,
Adams M.D.
,
Hunkapiller M.W.
,
Myers E.W.
,
Venter J.C.
more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue :
Brain .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE OF 1-33
tissue :
Liver .
9.
"Parathyroid hormone-related protein purified from a human lung cancer cell line."
Moseley J.M.
,
Kubota M.
,
Diefenbach-Jagger H.
,
Wettenhall R.E.H.
,
Kemp B.E.
,
Suva L.J.
,
Rodda C.P.
,
Ebeling P.R.
,
Hudson P.J.
,
Zajac J.D.
,
Martin T.J.
Proc. Natl. Acad. Sci. U.S.A.84:5048-5052(1987)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 37-52
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ALTERNATIVE SPLICING (ISOFORM 3)
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : CHARACTERIZATION OF OSTEOSTATIN ACTIVITY
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : CHARACTERIZATION OF OSTEOSTATIN ACTIVITY
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : CHARACTERIZATION OF OSTEOSTATIN ACTIVITY
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : CHARACTERIZATION OF OSTEOSTATIN ACTIVITY
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOCYTOPLASMIC SHUTTLING
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEAR LOCALIZATION SIGNAL
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR OF 37-70
20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 103-130
21.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.94 ANGSTROMS) OF 48-70 IN COMPLEX WITH PTH1R;INTERACTION WITH PTH1R;MUTAGENESIS OF ARG-57; PHE-59; LEU-60; LEU-63; ILE-64 AND HIS-68
22.
"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T.
,
Jones S.
,
Wood L.D.
,
Parsons D.W.
,
Lin J.
,
Barber T.D.
,
Mandelker D.
,
Leary R.J.
,
Ptak J.
,
Silliman N.
,
Szabo S.
,
Buckhaults P.
,
Farrell C.
,
Meeh P.
,
Markowitz S.D.
,
Willis J.
,
Dawson D.
,
Willson J.K.V.
,
Gazdar A.F.
,
Hartigan J.
,
Wu L.
,
Liu C.
,
Parmigiani G.
,
Park B.H.
,
Bachman K.E.
,
Papadopoulos N.
,
Vogelstein B.
,
Kinzler K.W.
,
Velculescu V.E.
more...
Science314:268-274(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT [LARGE SCALE ANALYSIS] THR-169
23.
"Deletion and point mutations of PTHLH cause brachydactyly type E."
Klopocki E.
,
Hennig B.P.
,
Dathe K.
,
Koll R.
,
de Ravel T.
,
Baten E.
,
Blom E.
,
Gillerot Y.
,
Weigel J.F.
,
Krueger G.
,
Hiort O.
,
Seemann P.
,
Mundlos S.
Am. J. Hum. Genet.86:434-439(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS BDE2 PRO-44 AND PRO-60